BIO 361 Lecture Notes - Lecture 19: Immune Complex, Wwcd, Monoclonal Antibody

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The key to immunoglobulin synthesis is that they come from b cells, which are the only cells that make such a range of immunoglobulins. There is a sequential series of events required to make a complete repertoire of immunoglobulins. The basic concepts of clonal selection and expansion is that in early steps of antibody production, it is associated with b cell precursor expression of surface bound igm (pentamer). The surface bound igm looks like secreted iggs that can recognize antigens. Binding of antigens to the surface cell igms signals the proliferation of the particular b cell precursor, however, more steps are required to secrete molecules. Engagement of antigens by surface bound igms is a signal to b cell precursors, and as b cells mature, they begin to make a whole range of igms which eventually secrete. Igd and igm are early molecules that are secreted in lower amount, which are eventually replaced with iga and igg molecules.

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