BIO 361 Lecture Notes - Lecture 27: Flavoprotein, Periplasm, Sdhb

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Remember that glycolysis consumes nad+, and so nad+ must be regenerated. One of the ways is to convert pyruvate into lactate. The electron transport chain and oxidative phosphorylation works to meet these functions. The electron transport pathway does a good job of keeping the krebs cycle and the glycolytic pathway going because of the regenerated oxidized redox intermediates that are present in the mitochondria and are also exported into the cytosol. The other purpose of the electron transport pathway is to provide the driving force for atp synthesis. The driving force for mitochondria is purely the proton gradient in the mitochondrial membrane. The atp synthase makes use of this gradient. The inner membrane is impermeable; therefore, solutes only permeate via transport mechanisms. Presence of protein on the inner membrane illustrates the location of cellular activity. Illustrated is the strategy that the mitochondria employ to capture reducing equivalents from the krebs cycle as well as glycolysis (nadh generated during glycolysis).

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