BIO 361 Lecture Notes - Lecture 20: Phosphorylation, Isozyme, Pyruvic Acid
3 Feb 2021
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Glycolysis can be split into a preparatory stage that consumes atp and a payoff stage that produces atp. Glycolysis follows a chemical logic that activates and reorganizes the intermediate metabolites to promote reactions. Glycolytic enzymes act as classical examples of regulation through induced fit binding and allosteric modulation. The conversion of fructose 6-phosphate to fructose 1,6-bisphosphate is the committed step of glycolysis. Different isozymes of glycolytic enzymes control activity in different tissues. Phosphorylate glucose so that it can be trapped in the cell. Glucose-6-phosphate (-oh on the c1) converted to fructose-6-phosphate (-oh on the c2 position) a. ) One of the best ways to break a c-c bond is to put an -oh group next to the carbon you want to break off promotes breakage at certain spots. Phosphorylate the fructose-6-phosphate molecule so that the -oh group which is located at the c1 position. Break fructose 1,6 bisphosphate to make 2 3-carbon trioses (sugar molecules) these are blocked in the cell.
