BIO 203 Lecture Notes - Lecture 26: Antigen Presentation, Major Histocompatibility Complex, B-Cell Receptor

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Cell-mediated immunity: immune cells use contact with pathogens/abnormal cells and subsequent contact-dependent signaling process to neutralize them. Humoral immunity: secreted proteins carry out the immune response. B cells, helper t cells, and cytotoxic t cells directly encounter and recognize antigens: each of them produce identical copies of themselves, start to express proteins and genes needed for their function in attacking. T cells direct attack antigen bearing cells. Cytokines: lymphocytes (b and t cells) encounter antigens and bind to them using specific receptor proteins, lymphocytes respond to contact-dependent signaling by proliferating and changing gene expression, lymphocytes kill microbes or abnormal cells. Remember: the second response to a particular antigen is always stronger and faster than the first response. Antigen: small fragment of a protein, lipid or carbohydrate: example: 8-16 amino acids in a folded protein, thousands of potential antigens in the same protein, millions on a microbial cell. Each adaptive immune cell only recognizes one potential antigen.

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