HP 127 Lecture Notes - Lecture 14: Natriuretic Peptide, Nitric Oxide, Sympathetic Nervous System
28 Mar 2019
School
Department
Course
Professor
Document Summary
While tissues consume oxygen and produce co2, the concentration of either will signal to the cells to vasodilate or. If there is an increase in perfusion pressure, it causes the vessel to stretch, which stimulates vasoconstriction to balance out. What is metabolic regulation? vasoconstrict based on how much flow is going to specific cells. What is myogenic regulation? the pressure (keep flow stable despite changes in overall pressure) Endothelial factors: cause smooth muscle to react, endothelin-1: vasoconstrictor produced by endothelial cells. Extrinsic control of blood flow: (maintenance of whole-body blood pressure) Main goals: provide brain and heart blood supply (at the expense of other organs and tissues) Radius of arterioles regulated by extrinsic mechanisms to controle map. Sympathetic nerves release norepinephrine, which causes vasoconstriction (general) Not sympathetic nerve endings, but very similar effects. Dilation to skeletal muscle and heart increases blood flow. Constriction to gi tract and kidneys decreases blood flow.
