ENS 333 Lecture 3: Cardiovascular 3
18 Oct 2016
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Skeletal muscle abnormalities in diastolic dysfunction with preserved ejection fraction. Paper came out last year using rats with systolic dysfunction: stiff hearts that do not fill properly, hypertensive rats, hfpef = heart failure with preserved ejection fraction. Width of the pressure volume loop is about the same as ejection fraction. September 19, 2016: lvedp = left ventricular end diastolic pressure. Higher in heart failure rats diastolic dysfunction: left ventricular mass is bigger concentric hypertrophy. Rats with heart failure (white bars) have slight more type 1 fibers and slight fewer type 2 fibers: cross-sectional area of these fibers are substantially smaller, evidence of atrophy. Fatigue index measure of rate of fatigue. Skeletal muscle abnormalities in diastolic dysfunction with preserved ejection fraction can you. As you increase stimulation frequency using an electronic stimulator (sending pulses to the muscle), you can generate more force.
