BIO207 Lecture Notes - Lecture 2: Intracellular Parasite, Quorum Sensing, Virulence Factor
Document Summary
General: gram-negatives have an lps: can produce a disease without an exotoxin. ); bacteria infect a living organism prior to infecting you: three distinct mechanisms of how you get infected, ingestion: vector borne, inhalation: droplet, airborne, open exposure: contact, vector borne, common vehicle, open wounds and burns. Shiga like toxin (has very specific entrance point: enters through gb3 receptor which is unique to erythrocytes and endothelial cells, meaning shiga like toxin only kills rbcs and blood vessel cells) Shiga toxin travels to kidneys and can destroy kidneys (big reason why people die from this) Can"t treat with antibiotics because more phages will be produced which produces more toxins. Locus of enterocyte (make eukaryotic cell produce receptor for the ligan they use to adhere; make sthe cell go from flat to curved so membrane surrounds the e coli, and the biofilm cannot be taken out) Create their own receptor and enterocyte lives inside the large intestine; doesn"t kill the cell.
