30:718:409 Lecture Notes - Lecture 12: Sympatholytic, Adrenergic, Doxazosin

• School: Rutgers University
• Department: Pharmacology and Toxicology
• Course: 30:718:409
• Professor: Dr. Lavoie and Dr. Chakalamanil

Document Summary

Binds to alpha receptor but does not stimulate generates an electrophile which can undergo nucleophilic attack at the receptor. Long doa used for chronic conditions like pheochromocytoma. Indication: treatment of sweating and hypertension associated with pheochromocytoma Pheochromocytoma is a rare tumor of adrenal gland tissue. It results in the release of excess epinephrine and norepinephrine, adrenergic neurotransmitters that control heart rate, metabolism, and blood pressure. The net result is sympathetic stimulation with an increase in blood pressure. Off-label uses had been for the treatment of frost bite and raynaud"s syndrome to improve blood flow to the extremities and to improve urinary flow in males with. Raynaud"s disease is a rare disorder of the blood vessels, usually in the fingers and toes. It causes the blood vessels to narrow when you are cold or feeling stressed. When this happens, blood can"t get to the surface of the skin and the affected areas turn white and blue.