01:694:301 Lecture Notes - Lecture 24: Nitrogen Fixation, Pteridine, Nitrogen Balance
14 Nov 2018
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Document Summary
Chapter 24 biosynthesis of amino acid": the pathways of biosynthesis are ancient (luca), many of the intermediates in energy transduction pathway play a role in biosynthesis allowing interplay b/w anabolic and catabolic pathways. Balance created b/w degradation for energy mobilization and synthesis of starting material: aa synthesis requires solutions to 3 problems, nitrogen is essential part of aa; biological systems need to transform n n to useable nh3. 23: glutamine and glutamate can act as aa nitrogen donors, be able to identify the various derivatives of thf and be able to complete the thf worksheet (fig. 1-c unit can exists in 3 oxidation states (fully oxy co2 is carried by biotin not thf) 1-c unit is interconvertible n5,n10-methylenethf can be reduced to n5-methylthf or oxidized n5,n10-methenylthf. Sam is synthesized by the transfer adenosyl group from atp to sulfur atom of methionine: triphosphate group of atp is split to pyrophosphate and orthophosphate, pyrophosphate is then hydrolyzed to 2 molecules pi.
