01:146:328 Lecture Notes - Lecture 19: African Trypanosomiasis, Chagas Disease, Kinetoplast

• School: Rutgers University
• Department: Cell Biology and Neuroscience
• Course: 01:146:328
• Professor: A.Keating

Document Summary

Disk of interlocking dna circle (kdna: maxi-circles: ~50 copies, mini-circles: 5,000 to 10,000 copies, concatenated mass interconnected complex network, some kind of mitochondrial function, some kind of metamorphosis transformation between life cycle forms, basal body. Associated with the outer surface of the mitochondrial membrane. Basal body and kinetoplast close together: 3 major human infections, human african trypanosomiasis, ha7 = sleeping sickness. Amastigote = ld body: mastigote = whip flagellum. Promastigote: flagellum locomotion and attachment, in insect vector. Trypomastigote (tryp: 4 basic types, long, slender in mammal, stumpy in mammal, infective to insect, procyclic in insect, metacyclic in insect, infective to mammal, glycosome. Compartment surrounded by membrane in which many enzymes involved in glycolysis are located. In mammal: lots of glucose, human normal blood glucose level is 70-110 mg glucose / 100ml, generate atp exclusively through glycolysis, mitochondrion is repressed and not functional at this point. It lacks most components of citric acid cycle and the etc.