01:146:328 Lecture Notes - Lecture 10: Lymphadenopathy, Tsetse Fly, 15Th Parallel North
18 Mar 2016
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Document Summary
Found in mitochondria associated with inner surface of mitochondrial membrane: kinetosome. Kinetosome is associated with outer surface of mitochondrial membrane and function is to anchor flagellum. Kinetosome and kinetoplast are indirectly connected always close to each other: ktdna kinetoplast dna. 2 classes of circular dna: maxi-circles ~50 copies, mini-circles ~5000-10,000 copies. Concatenated mass interconnected into a complex network. May function in metamorphosis (from one form to another during life. Involved in mitochondrial function cycle: three major human infections, human african trypanosomiasis (hat, chaga"s disease, leishmaniasis. Parasite develops in anterior part of vector in digestive tract. Heteroxeneus asexual reproduction takes place in vertebrate and invertebrate hosts. Glossina ingests metacyclic tryps slender tryps in blood blunt posterior end (not infective) stympy tryps in blood but do not multiply (not infective) ingested by glossina epimastigotes metacystic tryps. Slender tryps multiple by binary fission in body fluids (blood, lymph, spinal fluid) Procyclic tryps are found in fly"s midgut and multiple by binary fission.
