01:119:116 Lecture Notes - Lecture 26: B-Cell Receptor, Disulfide, Epitope

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violetseal1

18 Jun 2020

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43. 2 and 43. 3: components of adaptive immunity. Most are proteins or large polysaccharides on surfaces of pathogen or blood cells r tissue cells from other individuals: epitope= specific region exposed on surface of ag molecule. B cells and t cells specific for a specific epitope: antigen recognition by b cells and antibodies, structure of b cell receptor. > 2 identical heavy chains + 2 identical light chains. Transmembrane region near one end of each heavy chain= anchors receptor in b cells" plasma membrane. > 2 identical ag-binding sites: b cells activation by ag. Type of ag: intact ag on pathogen or circulating free in body fluid. When no pathogen present no ag b cell inactive. When pathogen ag binds to b cell ag receptor b cell activation. B cell becomes plasma cell secrete soluble form of receptor= antibody= immunoglobulin (lg) > antibodies= same structure as b cell receptors= but not membrane-bound.

Related Questions

Which of the following statements about induction or maintenance of T cell tolerance is NOT true?

	a.	Peripheral T cell tolerance to an antigen may be induced by persistent and repeated stimulation of lymphocytes by that antigen in tissues.
	b.	Peripheral T cell tolerance results when T cells recognize antigen in the setting of an innate immune response to the antigen.
	c.	Peripheral T cell tolerance to some antigens is induced when mature T cells recognize antigen and bind B7-1 or B7-2 via the inhibitory CTLA-4 receptor.
	d.	Peripheral T cell tolerance results when mature naive T cells recognize antigens without adequate B7-1â or B7-2âmediated costimulation.
	e.	Central tolerance is induced when immature developing T cells in bone marrow or thymus encounter self-antigens.

chocolateporpoise530

indicate whether you think the statements are true or false, and explain your reasoning. In each of your answers, provide 1-2 specific examples that support your position. (Each of your four answers is worth five points):

A) Memory cells require fewer distinct signals to be activated than naiÌve cells require.

B) Both B cells and T cells undergo âclonal selectionâ after they are activated by antigen.

C) A B cell is only able to present antigen to a T cell that includes the epitope to which the

B cellâs receptor bound.

D) T cells can recognize peptide antigens in the context of MHC I and MHC II regardless of

whether they are Thelper or Tcytotoxic cells.

E) B cells and T cells can both still make productive antigen receptors via V(D)J

recombination even if no P-nucleotides are introduced during the process.

F) Allelic exclusion takes place when a naiÌve T or B cell encounters its specific non-self antigen for the first time and determines whether or not to become activated.

G) B cells have more chances to make a productively rearranged antigen receptor than T cells do.

H) A majority of immature T cells developing in the thymus will survive both positive and negative selection.

I) The reason why T cells are the only type of white blood cell that requires maturation in a specialized organ outside the bone marrow is because they are the only ones that must have antigen processed and presented to them before they can be activated.

violetbear615

Host Defenses Activity

Our ability to fight off infection is three fold. Below is a list of terms that deal with our defenses. Match the definition with the terms on this sheet and then fill in the attached diagram with the terms below.

Host Defenses

1st Line of defense ___G_
2nd line of defense ____
3rd line of defense ____
Innate, nonspecific immunity____
Acquired, specific immunity____
T lymphocytes____
Complement____
Physical barriers____
Phagocytosis____
Chemical barriers____
Inflammatory response____
Fever____
B lymphocytes _____

Matching Definitions

A. immunity present at birth, provide nonspecific resistance to infection
B. Adaptive immunities: Immunity that develops after the interaction of antigens with the immune system
C. Many different types, involved in cell-to-cell contact or CMI
D. barrier that blocks invasion at the portal of entry
E. Protective cells and fluids; inflammation and phagocytosis
F .Acquired with exposure to foreign substance; produces protective antibodies and creates memory cells
G. Skin and mucus membranes
H. Bile, stomach acid, skin pH, lysozyme
I. Surveys tissue and discover microbes and dead or injured cells and removes them
J. 26 blood proteins that work to destroy bacteria and viruses
K. Rubor, tumor, calor, dolor
L. Initiated by circulating pyrogens which reset the hypothalamus to inhibit the growth of microbes
M. Responsible for AMI and production of antibodies

01:119:116 Lecture Notes - Lecture 26: B-Cell Receptor, Disulfide, Epitope

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