01:119:115 Lecture Notes - Lecture 7: Lipid Bilayer, Membrane Fluidity, Membrane Lipids
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15 Feb 2018
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Overview: life at the edge: the plasma membrane separates the living cell from its nonliving surroundings, this thin barrier, 8 nm thick, controls traffic into and out of the cell. Like all biological membranes, the plasma membrane is selectively permeable, allowing some substances to cross more easily than others. Membrane models have evolved to fit new data: models of membranes were developed long before membranes were first seen with electron microscopes in the 1950s. In 1915, membranes isolated from red blood cells were chemically analyzed and found to be composed of lipids and proteins. Membranes differ in thickness, appearance when stained, and percentage of proteins: membranes with different functions differ in chemical composition and structure. Second, measurements showed that membrane proteins are not very soluble in water: membrane proteins are amphipathic, with hydrophobic and hydrophilic regions. If membrane proteins were at the membrane surface, their hydrophobic regions would be in contact with water.
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