BIO-1 Lecture Notes - Lecture 9: Endosome, Low-Density Lipoprotein, Pinocytosis
Document Summary
Lysosomal pathway targeting signal, mannose 6 phosphate (m6p) Proteins destined for lysosomal pathway are all glycosylated and contain a special. Lysosomes are vesicles containing many kinds of digestive enzymes the membrane of lysosomes is usually underlain by a thick later of glycosylated proteins that prevents digestion of the membrane. Often contain electron dense material that is the remains of digested material. Contain many digestive enzymes (acid hydrolases) ph of ~5. Protein with m6p binds to m6p receptors in trans golgi. Incorporated into vesicle that goes to late endosome. In late endosome m6p protein detaches from receptor due to low ph (ph6) Newly made lysosomes are called primary lysosomes. Secondary lysosomes may be recycled by fusing with endosomes. The digestive enzymes are not degraded by digestive process can be used over and. After lysosomal proteins leave golgi, they fuse with late endosomes. In late endosomes, lysosomal proteins and their receptors dissociate due to low ph.
