NUTR 30300 Lecture Notes - Lecture 9: Lipid Peroxidation, Cardiovascular Disease, Chain Reaction

• School: Purdue University
• Department: Nutrition Science
• Course: NUTR 30300
• Professor: Jay Burgess

Document Summary

Molecules are most stable when the electrons in their orbitals are paired and spinning in opposite directions. Free radicals are chemical species with unpaired electrons. Si(cid:374)(cid:272)e ele(cid:272)tro(cid:374) pairi(cid:374)g is desired for opti(cid:373)al sta(cid:271)ilit(cid:455) free radi(cid:272)als (cid:858)steal(cid:859) ele(cid:272)trons from other molecules. A(cid:374)tio(cid:454)ida(cid:374)ts usuall(cid:455) (cid:272)a(cid:374) do(cid:374)ate a(cid:374) ele(cid:272)tro(cid:374) without (cid:858)steali(cid:374)g(cid:859) fro(cid:373) a(cid:374)other (cid:373)ole(cid:272)ule. Pufa especially susceptible leading to lipid peroxidation. Protects ldls from oxidation, reducing risk for cardiovascular disease. Vitamin c, main water-soluble antioxidant in the body, can regenerate vitamin e. Selenium as part of the enzyme glutathione=peroxidase, complements vitamin e. Vitamin e is destroyed by exposure to oxygen, metals, uv light and heat. Excess excreted, diarrhea side effect of high intake. Thousands of food substances in addition to 45 essential nutrients. Found in animal products that have health protective actions. Health-promoting compounds found in plant food many foods contain hundreds of phytochemicals not essential nutrients, no deficiency disease when removed from diet potential effects of phytochemicals inhibit cancer and cell death.