NROSCI 0081 Lecture Notes - Lecture 12: Classical Conditioning, Reinforcement, Radioactive Tracer
Document Summary
Pet produces 3d image of processes in body using radioactive tracer: cyclotron, functional pet localized changes in brain blood flow, molecular pet nt receptors. Changes in mechanisms that cause drug effect at the cellular level. Compensation for the continued presence of the drug: homeostasis. Adaptation: change in receptor density, change in receptor sensitivity. Drug disposition tolerance body is trying to get the drug out. Effect of the body on the drug. Occurs when repeated exposure reduces the amount of drug available at the target issue. Altered bioavailability of the drug: increased metabolism of the drug, increase liver enzymes = increase breakdown. Learned adaptation to the drug: learned based on repeated drug experiences within a certain combo of set and setting; psychological effect. Exposure to one drug leads to a diminished effect in another drug: dangerous when you consider the narrowing margin of safety and harmful side effects, dangers.
