BIOL 2299 Lecture Notes - Lecture 3: Methylation, Methyl Group, Heterochromatin
16 Mar 2016
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Bpa altering methylation in child and grandchild. No, just because they have the same sequence does not mean the sequence is being expressed the same. Gene expression on this mouse, varies in regards to bpa exposure. Grandparents and great-grandparents affect their grandchildren and great grandchildren. Can methylate certain parts of the histone, altering chromosomes, and. Eukaryotic dna packaged in nucleosomes: 8 histone proteins that make up a nucleosome, change conformation of chromatin by playing with the molecular tags on these 8 proteins. Modifications: cytosine methylation, hydroxymethylation, histone modifications. Changing from euchromatin to heterochromatin or vice versa: euchromatin unwound uncondensed, heterochromatin- dense area of chromatin with no expression, silenced, portions of dna can alternate between euchromatin and heterochromatin. Dna and histones: changes affinity in this particular region for other repressors or activators, occurs: 70-80% of cpg"s are methylated in mammals regulating the regulatory element of the gene: cpg methylation can be propagated during dna replication.
