GENE 500 Lecture Notes - Lecture 9: Circadian Rhythm, Proteasome, Intrinsic Activity
Document Summary
Hif-ia it has a very fast turnover; its made, then its destroyed, its made, then its destroyed. Crystalin lens proteins; its in your body for the rest of your life. Degradation it"s a (cid:449)a(cid:455) to (cid:396)e(cid:373)o(cid:448)e p(cid:396)otei(cid:374)s (cid:448)ia p(cid:396)oteaso(cid:373)e, u(cid:271)i(cid:395)uiti(cid:374)atio(cid:374) & autophag(cid:455) Proteasomes are very large protein-degrading molecular machines that influence many different cellular functions, including the cell cycle, transcription, dna repair, programmed cell death, or apoptosis, recognition of and response to infection by foreign organisms, and removal of misfolded proteins. The proteins that need to be degraded are tagged with a ubiquitin molecule (atp- dependent); eventually additional molecules of ubiquitin are added forming a polyubiquitin chain. Polyubiquitinylated target is (cid:396)e(cid:272)og(cid:374)ized (cid:271)(cid:455) u(cid:271) (cid:396)e(cid:272)epto(cid:396)s i(cid:374) the p(cid:396)oteaso(cid:373)e"s 19 (cid:272)ap, and the ub groups are removed by the deubiquitinase enzyme. Allosteric means a change in conformation of the enzyme when something binds to the enzyme anywhere other than the active site (allosteric regulator)
