CHEM 153A Study Guide - Final Guide: Proteolysis, Glycolysis, Covalent Bond
14 Jun 2016
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Document Summary
**metabolic regulation** in response to the overall needs of cells/ organisms. _based on targeting to proteasomes (ubiquitin: regulate enzymatic catalytic activity by changing or modifying protein structure to alter the protein activity. Small molecules bind through non-covalent interactions to the regulatory site. Satisfy the cell"s need, depend on [ligands] in the cell. Cascade to activate/ inhibit by the minute changes. Control gene expression (45-60 mins to build up enough e to regulate pathway) = hourly. Require lots of e: degrade old one and replace with a new enzyme. > lead to proteolysis: activation cleave a particular bond- turn on the enzyme e. g. zymogen (remove. Post-translational modifications e. g. phosphorylation -> any hydroxyl-containing aa attach fg to aa side chains. _not necessarily near the active site, as long as this causes a large enough shift to induce overall conformational change e. g. dephosphorylated form = inactive protein modification phosphorylation = activation.
