BIOS30344 Lecture Notes - Lecture 3: Tight Junction, Catecholamine, Cholesterol

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7 Dec 2017
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Ex: ldl endocytosis when failing ldl cannot be absorbed and causes build-up. Lumen empty space (down a tube or compartment) Diffuse from blood to cells with target receptors. 2-100 a. a. s - prepropeptide (non specific) to propeptide to peptide (specific) . Cholesterol modification inside gonads and some adrenal gland spots. Tyrosine side- group modification; epi and norepi; adrenals. Two tyrosines and two iodine; thyroid blebs containing colloid for t3 and t4 and c-cells for calcitonin. Made in advance in storage waiting for signal to release by exocytosis. Enzymatically dominated at trigger signals on demand only. Short because of degradation potential in blood as it is unbound - minutes. Membrane receptor no entrance tyrosine kinases or amplifiers. Modify existing proteins rarely production of new. Long because of carrier protein shuttles in blood; balance btw bound and unbound. Cytosolic/nucleic receptor gene expression produce new proteins. 2-3 months at a time to bind to colloid this slows response time a bit.

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