PS 101 Lecture Notes - Lecture 13: 5-Ht Receptor, Nicotinic Acetylcholine Receptor, Periaqueductal Gray

• School: Monmouth University
• Department: Political Science
• Course: PS 101
• Professor: Dr. T

Document Summary

Nmda receptor (enhances gaba and interferes with glutamate transmission) Receptors in the periaqueductal gray are = analgesia. , , k receptors; k = aversive effects. Na & causes increase in da levels (reinforcing) Anxiolytic effect is a release from punishing effects of aversive stimuli. Effects long term potentiation through the mesolimbic neurons and its. Reinforcing of alcohol is caused by ability to trigger the release of endogenous opioids. Levels of nicotine in the brain increases and is not destroyed by ache. Has both activation and desensitization effects (desensitizing increases nicotinic receptors) Reinforcing effect appears to be caused by activation of nicotinic receptors in the vta. Reinforcing effects of nicotine (ex: rimonobant = blocks. Brain has a medial habenula to interpeduncular nucleus pathway that can inhibit reinforcement. Cocaine binds w/ & deactivates da transporter proteins, which block reuptake of da after released from terminal buttons. Amphetamine = inhibits da reuptake, but stimulates da release from terminal buttons.