NROB60H3 Lecture Notes - Lecture 8: Catecholaminergic, Serotonergic, Ligand-Gated Ion Channel
Document Summary
Lecture outline: classes of neurotransmitters overview and review, neurotransmitter chemistry, cholingergic neurons, catecholaminergic neurons, serotonergic neurons, amino acidergic neurons (ionotropic) transmitter-gated channels (metabotropic) g-coupled receptors and effectors. Neuropharmacology continued: recall the difference between an agonist and antagonist discussed last lecture, receptors for acetylcholine and glutamate, and their agonists. Neurotransmitter video: anything in red is an agonist, anything in green is an antagonist. There are so many receptor sub-types, that all result in varying neuron behaviour. Not mentioned here, but mentioned in the video serotonin and dopamine => this table is by no means exhaustive! Cholinergic neurons: acetylcholine (ach, choline and acetate produce acetylcholine in the presence of chat (choline acetyl-transferase) Synthesized in all motor neurons: decline of acetylcholine during alzheimer"s disease, also involved in specific sympathetic and parasympathetic divisions and special circuits of the. Acetylcholine was the first neurotransmitter to be identified. Synthesis requires a special enzyme, (chat: chat is manufactured in the soma and transported to the axon terminal.
