BIO 3014 Lecture Notes - Lecture 4: Lipid Bilayer, Hydrophile

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Diffusion means the movement of molecules from one location to another across a membrane. Result of their random thermal motion. (random movement of a particle associated with the particle"s thermal energy) Direction- net flux always proceeds from higher to lower concentration. (moves high to low: magnitude of diffusion. Rate of diffusion obeys fick"s law (diffusion rate = ds * a. Ex: if the diffusion area increases then the size of the concentration gradient increases. Rate of diffusion depends on many factors: size of concentration gradient(dc/dx, size of the molecule used to calculate the diffusion coefficient (ds, diffusion area (a, diffusion through membranes. 10^3 to 10^6 times slower than the diffusion rates of the same molecules. Membranes act as barriers slowing down diffusion of molecules across their surfaces. Hydrophobic (water-fearing particle) interior of its lipid bilayer is the major factor limiting diffusion across a membrane.

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