BIOL 1201 Lecture : Ch16 Lecture Presentation Rev Spr 14
Document Summary
Cindy s. malone, phd, california state university northridge. Genetic information flows from dna rna proteins by asking then examining and analyzing. Including mendel, watson & crick, and others. Biologists still did not understand how gene expression occurred. The process of translating the information in dna. Genes carry the instructions for making and maintaining an individual. Damage a gene by creating a mutant. Then observe the resulting effect on the mutant"s phenotype. Nonfunctioning alleles are now called knock-out, null, or loss-of-function alleles. To test their hypothesis, beadle and tatum. Damaged genes in the bread mold neurospora crassa. Observed that defects in particular genes resulted in the mold"s inability to produce specific proteins. The results of their experiments inspired their one-gene, one-enzyme hypothesis. Proposed that each gene contains the information needed to make an enzyme. Srb and horowitz further tested the one-gene, one- enzyme hypothesis. They examined the production of the amino acid arginine. Requiring the action of three different enzymes.
