REAL ES 5 Lecture Notes - Lecture 24: Multiple Sclerosis, Theta Wave, Amygdala
Document Summary
Major depressive disorder (mdd) expected to be the second-leading cause of disability worldwide by. The star*d project results: a comprehensive review of findings. Difficult to determine treatments when first step is unsuccessful. The sequenced treatment alternative to relieve depression (star*d: using patients without adequate benefit from antidepressants. Overall remission rates at the end of 2 treatment stages = 50% (after 3rd step: 70% remission) Iv: good compared with other chronic medical illnesses, question is still how to match treatment to individual patient using clinical characteristics. Iii. rtms can produce effects that last beyond the last stimulation period. Intracortical inhibition (ici) and intracortical facilitation (icf: obtained through paired-pulse studies, reflect activity of interneurons in the cortex. Initial conditioning stimulus given (large enough to activate neurons but no influence on spinal cord: second stimulus (at suprathreshold level; large enough to evoke action potential) follows, ici largely mediated by neurons containing gaba.
