DANCEST 805 Lecture Notes - Lecture 40: Wnt3, Interleukin 22, Neutrophil
Document Summary
(to be used in combination of the slides from the lecture, some slides are pretty self- explanatory, so they are note specifically mentioned in here) There"s a close interaction between nutrition, intestine and immunity. Microbiota has a big influence the immune system microbiota interact with the intestine so, shapes the immunity. Bacteria can use the entry points of the nutrients need of a strong barrier. Absorptive epithelial cells make up most of the intestinal barrier. Absorptive epithelial cells (enterocytes) are connected by multiple ways but the most important is the tight junctions prevent the passage of components via the paracellular space. Goblet cells secret mucus prevent the bacteria to cross the barrier. Paneth cells located in the crypt bottom protect body against bacterial invasion. Synthesis and secretion of: antimicrobials (lysozyme, alpha-defensins, factors for stem cell function (wnt3, egf, proinflammatory factors (il17, il1beta)
