Microbiology and Immunology 3820A Lecture Notes - Lecture 2: Nod2, Sepsis, Aureus

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Learning objectives: the key properties of innate immunity, how barriers prevent pathogen entry into tissues, how the innate immune system recognizes and binds pathogens, extracellular versus intracellular pathogens. Innate immunity is the first line of defense against a pathogen. It is constantly ready to destroy a pathogen effective at stopping majority of pathogens at early stage. Immune system starts fighting right away: we want it to start as early as possible. Innate immune defenses: barriers, block pathogen entry into tissues. Innate cells & proteins: rapidly eliminate pathogens that enter tissues. If innate immunity is unsuccessful: certain innate cells initiate adaptive immunity to help eliminate the pathogen: the innate system might need help from adaptive immunity. If the barrier cant block the pathogen then the innate cells and proteins try fight it off. Immediately upon contact our innate system starts fighting: adaptive immunity can take 7-10 days to develop immunity.

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