BIO 11 Lecture Notes - Lecture 7: Rheumatoid Arthritis, Neuromuscular Junction, Diabetes Mellitus Type 1
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3 Sep 2020
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T cells bind with antigen infected body cell. Sees a cell that has been marked as foreign. Co-stimulatory signals are present after the binding. Normal self marker that is just messed up somehow (cancer) An antigen presenting cell (it has been infected by something) T cell antigen receptors bind to specific antigen-mhc complexes. T cells binding to other receptors/sites on apc, cytokines, interleukins. T cell binds with antigen infected body cell. Directly attack and kill antigens (class 1 mhc) Use lysis to destroy the infected cell. Activate b cells and cytotoxic t cells. Immunodeficiencies any condition that causes the immune system not to behave. Genetic prevents a person from producing b and t cells. Extremely prone to infection and unable to fight it. Aids: hiv causes the destruction of t lymphocytes. Die of other infection due to the virus. Autoimmune diseases: immune system lost the ability to distinguish self vs non self.
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Immunology worksheet help?
1. | In people infected with human cytomegalovirus, class I MHC andb2-microglobulin are produced, but very little mature class I MHCis found at the cell surface. Inhibition of which of the followingmolecules by human cytomegalovirus may account for thisphenomenon? | ||||||||||
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2. | Your chances of having the same MHC haplotype as your siblingare: | ||||||||||
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3. | Which of the following is the BEST example of self-MHCrestriction of T cells? | ||||||||||
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4. | MHC molecules: | ||||||||||
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5. | Tasmanian devils are a largely inbred population with littlediversity in the MHC. Which of the following would be a likelyoutcome of this? | ||||||||||
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6. | How many different MHC classical class I proteins does eachnucleated cell in a human heterozygous at the MHC locusexpress? | ||||||||||
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7. | MHC polymorphisms tend to cluster: | ||||||||||
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8. | A mutation that renders the MHC class II molecule DMnonfunctional would likely lead to: | ||||||||||
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9. | The human MHC locus is one of the most polymorphic regions ofthe genome. What does this mean? | ||||||||||
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10. | Which of the following is an example ofcross-presentation? | ||||||||||
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