MICRO 302 Lecture Notes - Lecture 3: Archaea, Electronegativity, Peptidoglycan

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Microbiology 302 Exam One
Chemistry Basics: Bonding and Non-Informational Molecules
Important Readings: Appendix I - pgs. A3-A15
Learning Objectives:
Draw a simplified bacterial cell and label where you find each of the four
macromolecules.
Describe the relative abundance of these macromolecules in bacterial cells.
Differentiate between ionic, covalent and hydrogen bonds and examples of each.
Draw a simple sugar molecule, describe the characteristics common to all carbohydrates
and give examples of modified sugars.
Diagram the process of forming polysaccharides and lipids from their respective
monomers. Explain how different bonding patterns lead to different bonding patterns
lead to different structures and functions in polysaccharides.
Explain how the structure of a phospholipid leads to the formation of a lipid bilayer in
water and how saturated and unsaturated fatty acids differ.
A simplified bacterial cell
Macromolecules
Polymers made up of subunits (monomers)
Each class of macromolecule has its own functions and distributions
Functional groups important
Proteins
Phospholipids
Nucleic acids
Carbohydrates
How are these macromolecules put together?
Bonding - Covalent Bonds
Strong bonds
Shared electrons
2 electrons = single bond
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Microbiology 302 Exam One
The macromolecules are polymers of covalently joined monomers
For example
Bonding - Hydrogen
Weak interactions
Hydrogen and an electronegative element
Common H-bonds between
H-O
H-N
Polar vs Nonpolar compounds
Other Weak Interactions
Ionic
Opposites attract (e.g. NaCl)
Group I and Group VII
Hydrophobic
Very important in protein folding to determine its function
Non Informational Macromolecules (Lipids and Polysaccharides)
If you do genetic analysis and delete certain genes, will you directly affect expression of
lipids or sugars?
Polysaccharides
Contain carbon, hydrogen and oxygen
Common sugars include
Pentose and hexose monomers
Sugar derivatives formed
-OH groups replaced
Complex polysaccharides
Glycoproteins, Glycolipids
Are all carbohydrates just C, H and O?? (additions and substitutions to a
monosaccharides)
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Document Summary

Draw a simplified bacterial cell and label where you find each of the four macromolecules. Describe the relative abundance of these macromolecules in bacterial cells. Differentiate between ionic, covalent and hydrogen bonds and examples of each. Draw a simple sugar molecule, describe the characteristics common to all carbohydrates and give examples of modified sugars. Diagram the process of forming polysaccharides and lipids from their respective monomers. Explain how different bonding patterns lead to different bonding patterns lead to different structures and functions in polysaccharides. Explain how the structure of a phospholipid leads to the formation of a lipid bilayer in water and how saturated and unsaturated fatty acids differ. Each class of macromolecule has its own functions and distributions. The macromolecules are polymers of covalently joined monomers. Very important in protein folding to determine its function. Are all carbohydrates just c, h and o?? (additions and substitutions to a monosaccharides) Differences in structure = differences in physical properties.

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