Chemistry CHEM S-20ab Lecture Notes - Lecture 28: Isoprene, Cholesterol, Ylide
30 Apr 2018
School
Department
Course
Professor
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chemical)transforma2ons)L4568()$59H3I<=$=1"4<689)MN)
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O
HO
HO
HO
OH
OH
O
O
O
glucose pyruvate
2
glycolysis
O
O
O
OH
+CO2
in(yeast
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O5?$4<H18$81"$)"368$3==547(<61$81<6$893I625943T5IQ)
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01"$J"=39A5V)(3T5I$52$7)9'G38"$9"Z'<9"6$81<34<I"$36$3$cofactor,$<I$81"$2594$52$3$$
81<34<I"$J<71567138"$L0>>M$)(<J"E$
[15?$15?$81"$0>>$)(<J"$=3I$=383()\"$81"$J"=39A5V)(3T5I$52$7)9'G38"C$$01<6$9"3=T5I$<6$$
81"$65'9="$52$81"$WX-$8138$43#"6$A9"3J$9<6"$3IJ$43#"6$A""9$A'AA()C$
S58"$15?$81"$0>>$)(<J"$8'9I6$3$85'H1$α]J"=39A5V)(3T5I$<I85$3I$"36)$β]J"=39A5V)(3T5IN)
NS
R
H
R'
Me
B: NS
R
R'
Me
TPP,
(thiamine,diphosphate)
TPP,ylide
O
O
O
O
+CO2
H
N
S
R
R'
Me
