BIOL 4570 Lecture Notes - Lecture 3: Pattern Recognition Receptor, G Protein–Coupled Receptor, Mannose Receptor
Document Summary
Key terms: respiratory burst, toll like receptors (tlrs, nod like receptors (nlrs, prr found on innate is cells of own body, prr, rig 1 like receptors, prr. Di and triacyl lipopeptides are in peptidoglycan bacterial cell wall dsrna is used in viral transcription. Cpg dna is methylated have dna methylases if not methylated cpg, it has bacterial origin. Gram negative tlr2/6, tlr2/1, tlr5, tlr4, tlr9. Virus tlr3, tlr7: can act as heterodimers, ligand binding domains are either exoplasmic (outside cell) or within lumen of endosomes, transmembrane and cytoplasmic (signal transduction) domain. Ikb is degraded by proteasome when it is phosphorylated nfkb is released and goes into nucleus promotes transcription. Ikb is phosphorylated by activation of ikb kinase (ikk) Interferon induce antiviral activity; makes normal cells act in antiviral way. Sensors for cytoplasmic viral rnas: epithelial cells of respiratory system, viral rnas bind to rig receptors that are associated with outer membrane of mitochondria.
