BIOL 4570 Chapter Notes - Chapter 6: Cytotoxic T Cell, Antigen Presentation, T Cell
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Generation of alpha: beta t cell receptor ligands: antigen processing ~ generation of peptides from native proteins, antigen presentation ~ peptide display at cell surface by mhc molecule. 6. 1 antigen presentation functions both in arming effector t cells and in triggering their. Effector functions to attack pathogen infected cells: cytotoxic t cells ~ cd8 t cells; primarily responsible for pathogen surveillance and cytolysis of somatic cells; function is to kill cells they recognize. 6. 3 peptides from cytosol are transported by tap into er and further processed before. 6. 4 newly synthesized mhc class i molecules are retained in er until they bind peptide: mhc class i deficiency ~ immunodeficiency due to defects in tap1 and tap2 have few. Mhc class i molecules on their cell surfaces: folding and assembly of complete mhc class i molecule depends on association of mhc class i alpha chain first with beta 2 microglobulin and then with peptide.
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1. | In people infected with human cytomegalovirus, class I MHC andb2-microglobulin are produced, but very little mature class I MHCis found at the cell surface. Inhibition of which of the followingmolecules by human cytomegalovirus may account for thisphenomenon? | ||||||||||
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2. | Your chances of having the same MHC haplotype as your siblingare: | ||||||||||
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3. | Which of the following is the BEST example of self-MHCrestriction of T cells? | ||||||||||
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4. | MHC molecules: | ||||||||||
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5. | Tasmanian devils are a largely inbred population with littlediversity in the MHC. Which of the following would be a likelyoutcome of this? | ||||||||||
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6. | How many different MHC classical class I proteins does eachnucleated cell in a human heterozygous at the MHC locusexpress? | ||||||||||
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7. | MHC polymorphisms tend to cluster: | ||||||||||
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8. | A mutation that renders the MHC class II molecule DMnonfunctional would likely lead to: | ||||||||||
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9. | The human MHC locus is one of the most polymorphic regions ofthe genome. What does this mean? | ||||||||||
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10. | Which of the following is an example ofcross-presentation? | ||||||||||
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