BISC 2539 Lecture Notes - Lecture 12: Regulatory Sequence, Transcription Factor, Eukaryote

• School: Fordham University
• Department: Biological Sciences
• Course: BISC 2539
• Professor: Michael Sekor

Document Summary

Differentcelltypessynthesizedifferentsetsofproteins manyprocesses arecommonto all cells manyprotein in common someproteinabundant in specializedcells inwhichtheyfunction and cannot be detected elsewhere. Atanyonetime humancellexpresses zogo gogoof approximately25kgenes celldeterminewhichgenetotranscribe two components. Gene regulatoryprotein influence chromatinstruc. tn of dna control region. Generegulatoryprotein t locationotbind ingite relative to promote different for eachgene. Eukaryoticgene regulation a mediator 24 subunitcomplex serve as intermediarybetween generegulatoryprotein trnapdy_ provideextendedcontact forgeneregproteins us justrnapolymerasealone. I muchlargerin eukaryotes thanprokaryotes providemoresurface area for proteinbinding. 37 r y not as large complex aseukaryote a 3rnapolymerase functions a rnatranscript extensiveprocess. G ensure the expression of mostgenes in the genome o whileactivatinga subsetof genes at all times. Transcriptionalmachinery rnap e creneraltranscription tactorscat cannot bind to promoter in absence of other regulatoryprotein. Regulatein interact w dnasequences promoterproximai element to initiate transcription to. Rnap as. tt gif interactw thguy promoterproximat element imitate transcription. Gail gali gall andgallo catalyzesteps in biochemical pathwayconverts gene. Each 4 genehas a or morecoral4 bindingsite remainsilent. Location 5 upstream of promoter zoo o folds orhigher.