BSC 1005 Lecture Notes - Lecture 5: Viral Pathogenesis, Endosome, Coronavirus
Document Summary
Forms tight seals between the membranes of the neighboring cells. 3. membrane pinching off (endosome formation: acidification of endosomes, receptor recycling, fusion with lysosomes. Function of trna to bring amino acids to mrna in an ordered fashion, translating the mrna code to protein sequence in the process. Travels from the center of the cell (endoplasmic reticulum) to the outer edge of the cell (plasma membrane) Pamp pathogen associated molecular patterns. examples include dsrna and viral proteins. Prr pattern recognition receptor; host proteins that detect pamp"s and activate cellular reponses. Seroconversion the point when antibodies against a virus become detectable in a patient"s blood. Multiple layers of host defense against infection primary barrier and chemical defense => intrinsic cellular response => innate immunity => adapted immunity. Toll-like receptors, localized on cell membrane or endosome membranes. Rna helicases (rig-i, mda5), localized in the cytoplasm. What do virtually all viral infections trigger the production of? interferons.
