NURS 306 Lecture Notes - Lecture 1: Proton-Pump Inhibitor, Aluminium Hydroxide, Gastric Acid
Document Summary
Peptic ulcer disease group of upper gi disorders characterized by the varying degrees of erosion of the gut wall. Most commonly found: lesser curvature of stomach and duodenum. Complications: cause: imbalance between mucosal defensive and aggressive factors. Hemorrhage, perforation aggressive factors- h, pylori, nsaids, acid, pepsin, smoking: h. pylori: gram-negative bacillius that can colonize in the stomach and duodenum. Most patients with pud have h. pylori infection but do not have ulcers. Bacteria alone does not cause ulcers: nsaids: anti-inflammatory drugs inhibit the biosynthesis of prostaglandins. Treatment of pud: alleviate symptoms: n/v, burning, abdominal discomfort. **drug therapy promotes healing, does not alter the disease process antiulcer drugs: antibiotics, antisecretory agents, mucosal protectants, antisecretory agents to enhance mucosal, antacids actions, eradicate h pylori, reduce gastric acid, enhance mucosal defenses. Breath tests serologic tests stool tests two or three antibiotics and proton pump inhibitor or h2ra. Antibacterial drugs for pud: clarithromycin (biaxin): distortion of taste, nausea, diarrhea amoxicillin: best in neutral ph.
