BMS 460 Lecture Notes - Paclitaxel, Nidogen-1, Proteoglycan
26 Apr 2014
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Document Summary
Golgi is an organelle, not an extension of ser. As with all cellular organelles, the golgi has to grow and divide and has to be inherited. The golgi decides whether a given protein will leave the cell or be delivered to the cell surface or another destination. Golgi sorts and modifies cell products such as hormones, growth factors and digestive enzymes. E. g. , addition of mannose-6-phosphate (m6p) tags to lysosomal enzyme precursors. In inclusion-cell (i-cell or mucolipidosis ii) disease, golgi is unable to tag proteins with m6p because of a defective phosphotransferase. This results in secretion of lysosomal enzyme precursors from the cell instead of targeting them to lysosomes, resulting in impaired lysosomal function leading to cellular inclusions and death in childhood. Golgi apparatus is fragmented in neurodegenerative diseases and cell death. Neuronal golgi fragmentation is an early and probably irreversible lesion in neurodegeneration, caused by a variety of mechanisms. Acid hydrolases active at ph 5 (inside lysosome)
