ANSC 340 Lecture Notes - Lecture 13: Adenylyl Cyclase, Theca Interna, Granulosa Cell
12 Oct 2016
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Influence of feeding fsh to board daily upon sperm production: No change; fsh is a glycoprotein thus not orally active. Influence of elevated endogenous fsh levels upon aromatase activity within granulosa cells: Increase; fsh and its receptor facilitates the conversion of testosterone to estrogen (and aromatase is the enzyme that makes that possible) Theca interna cell: lh binds to lh-r, activates enzymes necessary to convert cholesterol to testosterone. Granulosa cell: fsh binds to fsh-r, activates aromatase which is necessary to convert testosterone to estrogen. Fsh binds to fsh-r on cell membrane. Estrogen enters into the blood stream (lipid soluble; no receptor needed to pass through lipid bilayer) (fast) steroid action. Adenylate cyclase activates conversion of atp to camp. >>this last step is the main difference from protein hormone action<< Hormone binds to receptor (usually in cytoplasm; can be in nucleus) Transcribed mrna is translated by ribosome into specific proteins which alter cell activity.
