BIOS 20187 Lecture Notes - Lecture 23: Tata Box, Tata-Binding Protein, Chromatin
26 Dec 2019
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Document Summary
Genomic dna organized into chromatin = chromatin remodeling. Steps: initiation, tata box= promoter element where tbp binds, along with other general transcription factors (gtfs) and the rna pol ii bind to promoter, rna pol gets phosphorylated and begins the transcription process, while the. Polyadenylation- adding a bunch of adenines to then 3" end of the mrna after it has been cut (signal= aauaaa). Splicing- introns removed from pre-mrna, leaving only exons, the material that is necessary for translation (real coding sequences) Promoter-proximal elements: any sequence near a promoter that has something to do with modulating transcription. Enhancers: area 50-150 bp above a gene that when activated increase transcription or transcription probability. Functional domains: areas of regulatory protiens that allow them to be multifunctional. Interacting with protiens in transcriptional complex or regulatory sequences. Activators: turning promoter or enhancer on indirectly through interacting w/ sub protein complexes or recruiting proteins that modify chromatin structure.
