CAS BI 525 Lecture Notes - Lecture 3: Nuclear Membrane, Surface 3, Superoxide
1 Oct 2016
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Slide 38: there to control and dismutate superoxide ions (most dangerous form) into hydrogen peroxide. Sod1- in als- may not be the cause of the disease. Important in regulating number of cells in cell growth. Steps that lead to apoptosis: condensation of nuclear chromatin, compaction of cytosolic organelles and blebbing on the cell surface, decrease in cell volume (the cell shrinks, alteration of plasma membrane, phagocytosis. 1 and 2 should be at the beginning so there is not unwanted protein expression, cannot reproduce dna anymore and no reentering cell cycle. The other steps are there just to make the cell smaller. Blebbing of the surface plastic bag with some air, pinching plastic to make bubbles, to decrease surface and area of the original -- leads to compaction of cytosolic organelles. Main characteristic that starts the whole thing: condensation of nuclear chromatin and dna fragmentation. Necrosis break of nuclear envelope, release of cellular contents (slide 41)
