BIOL 313 Lecture Notes - Lecture 13: Creb1, Repressor, Synapsin
Document Summary
Used these organisms because they have nervous systems with huge, color-coded neurons. We will be looking at a set of neurons that drive contraction of the gill, particularly at the siphon and tail. Slug withdraws its sensitive gill for noxious stimuli. When you stimulate the siphon sensory, activates voltage gated ca2+ channels helping neurotransmitter release. Also releases calmodulin that activates adenylyl cyclase to activate camp. Ap in siphon sensory neuron, which opens v-gated channels, increasing nt release, but only by a little. This is not enough to trigger the gill motor neuron to fire. Activation of calmodulin, which activates adenylyl cyclase, in turn activating a bit of camp. Pinching the tail without training activates the facilitating interneuron, which releases nt serotonin. Activates a g-protein, which activates adenylyl cyclase, which then activates camp. Pairing these two systems together during training (siphon and tail pinching) creates a greater increase of camp.
