MCELLBI 32 Lecture Notes - Lecture 11: Efferent Nerve Fiber, Tonicity, Mannitol
20 Nov 2018
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Getting through the blood brain barrier: patients with brain tumors are often given a hyperosmotic solution of mannitol along with the other chemotherapeutic drugs, hydrophilic medicine can get into brain with hyperosmotic solution (cells shrink) Spinal cord anatomy: there is a number of diseases that cause demyelination of axons. What defect would you expect in someone with demyelinated central root neurons (efferent neurons, some control skeletal and muscle contraction): impaired/slow limb movement. Brain anatomy: folds in cerebral cortex are to increase surface area to accommodate increase in neurons which account for complex cognitive thinking. Case study #1: intractable hiccups: medulla/pons = vestibular system, breathing. Case study #2: ataxia: cerebellum = coordinates movement. Case study #3: left hemineglect: parietal lobe = sense of touch (and pain) is processed by the somatosensory cortex, muscle awareness. Case study #4: behavior change: frontal lobe = planning, reasoning. Case study #5: arm weakness: left motor cortex controls movement on right side, directly controls muscle movement.
