BIO-1801 Lecture Notes - Lecture 5: Atp Hydrolysis, Phosphate, Endergonic Reaction

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Nonspontaneous reactions may be driven using chemical energy: energetic coupling between exergonic and endergonic reactions allows chemical energy released from one reaction to drive another reaction. If you don"t regenerate nadh+ then your body will stop functioning: readily donate electrons to other molecules. Atp transfers energy via phosphate groups: atp is the energy currency for cells and provides fuel for most cellular activities, atp forms bonds between 3 negatively charged phosphate groups. High energy bonds store a large amount of potential energy. Atp hydrolysis releases free energy: hydrolysis of the bond between the 2 outermost phosphate group results in formation of adp and. Pi (inorganic phosphate, h2po-4: atp --> adp + pi + energy. How does atp drive endergonic reactions: energy released during atp hydrolysis is transferred to a substrate by phosphorylation, phosphorylation , usually causes a change in the proteins shape, exergonic phosphorylation reactions are coupled to endergonic reactions.

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