KINE 3012 Lecture Notes - Lecture 31: Angiotensin, Parasympathetic Nervous System, Epithelium
7 Apr 2018
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Document Summary
Aldosterone is released from the adrenal cortex and acts predominately on the distal and collecting ducts epithelial cells: this is a steroid hormone, meaning it is lipid soluble. Its receptor is in the cytoplasm of the cell. Aldosterone has to di use into the cell to nd its receptor: once it nds its receptor, the aldosterone bound to the receptor can then translocate to the nucleus. The active steroid receptor can interact with the dna in the nucleus to get it to produce di erent sequences and transcription factors: the transcription of speci c genes will take place and new mrna will be produced. That mrna will then be translated into new proteins that will be used by the cell. Aldosterone will increase the synthesis of the proteins that are needed for the transport and reabsorption of sodium ions: we can"t really change sodium reabsorption without changing potassium reabsorption too because of the sodium potassium pump.
