ANSC 3301 Lecture Notes - Lecture 1: Vasopressin Receptor 1B, Vasopressin Receptor 1A, Neurogenic Diabetes Insipidus
Document Summary
Avpr1b, also called arginine vasopressin receptor 3, gq coupled receptor. Nephrogenic (problem with receptor) diabetes insipidus (high levels of solutes within the blood, lost many bodily fluids) If dehydrated, you will have a high osmolarity in your blood. Send signal to posterior pituitary to produce and release vasopressin. A peptide hormone (adh) produced in the hypothalamus and released by the pituitary gland. Release: increasing plasma osmolarity detected by osmoreceptors in the hypothalamus. Increases water reabsorption in the collecting duct by increasing the number of aquaporins. Inhibition: increasing blood pressure detected by stretch receptors in the atria and baroreceptors in the carotid and aortic bodies. Urea is also recycled and vasopressin plays a role in urea reabsorption. Vasopressin promotes reabsorption of urea- important so water doesn t interrupt the osmotic gradient. Without vasopressin, urea stays within the nephron and excreted. A steroid hormone produced by the adrenal cortex. Targets cells in the distal tubule and collecting ducts.
