KINE 2475 Lecture Notes - Lecture 10: Tropical Sprue, Megaloblastic Anemia, Folate Deficiency
13 Jan 2020
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Hypomethylation, folic acid metabolism & vitamin b12: folic acid deficiency, synthesis & metabolism of tetrahydrofolate (thf, biochemical actions & physiologic roles of thf (dntps, folic acid & hyperhomocysteinemia, vitamin b12 metabolism & deficiency (pernicious anemia) Folic acid (folate, folacin): folin- leaf, yellow orange, slightly soluble in water, animals cant synthesize folic acid, dietary requirements: Rdi: 400 ug/day (pregnant 800 ug/day) , greater than >1000ug may cause toxicity: folic acid is in leafy green vegetables, mushrooms, asparagus, liver, kidney, steak, yeast. But its destroyed by cooking & exposure to reducing agents: we need it for cell synthesis in gut, skin, tongue & bone marrow. Folate deficiency: folic acid is most common form of vitamin deficiency world wide, more prevalent in underdeveloped counties in tropics least marginal folic acid deficiency. Folate deficiency is involved in megaloblastic anemia (b12: tropical sprue: malabsorption syndrome along w/folate deficiency. Folate deficiency, effects: neural tube defects in fetus (spinobifida)
