KINE 1020 Lecture Notes - Lecture 19: Autoimmune Disease, Beta Cell, Public Health Genomics
7 Dec 2018
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Document Summary
The childhood disease cured by canadians: treated by the discovery of insulin, was a death sentence before this discovery, causes problems through the byproduct of excess fat metabolism, namely ketones, prevents storing fat and building muscle. Insulin is absolutely vital to life, can"t live without it. Insulin triggers the absorption of glucose/fatty acids in to the cells, otherwise they remain in the blood stream. Insulin acts as a key to a lock that allows glucose into the cell: canada"s biggest discovery. Type 1 diabetes can be diagnosed at any age, but the highest incidence rate is during the teen years. (~0. 05% change of developing t1d in teens) The pancreatic cells that produce insulin are called beta cells in an area called the islet of. Pathophysiology: autoimmune disease- t1d patient"s bodies destroy their beta cells and therefore no insulin is produced. Genetic link: studies of identical twins.
