HIST 3791 Lecture Notes - Lecture 47: Histoplasma, Fungemia, Mononuclear Phagocyte System
Document Summary
Malassezia furfur (pityriasis versicolor): lipophilic, commensal yeast on the skin. An overgrowth can cause: -macules, non-itchy, scaly rash. Catheter associated fungemia: for most people, it"s not a big deal. If we have something growing on the skin, if we put a catheter in the skin, we put the fungus on the outside on the inside-we treat the catheter fungemia with a topical or oral azole. Spores are inhaled into the lungs, germinate, invade and destroy other organs and tissue. In healthy individuals, they cause mild and self limiting infections. Fungus grows in soil, produces spores, wind carries the spores (it"s a great environment for fungi to grow because the air is quite dry)-over 1/3 of the population is infected. Spores germinate in the lungs and form spherules filled with endospores. Spherules rupture and release endospores, each of which can lead to a new spherule. Can spread to bone, skin, gi tract and gu trace in rare cases.
