CRIM 2653 Lecture Notes - Lecture 58: Diabetes Mellitus Type 2, Insulin Resistance, Brown Adipose Tissue
23 May 2020
School
Department
Course
Professor
Document Summary
A disease of aging & more prevalent in elderly but not completely absent in young"uns. Type 2 dm is also genetically inherited, and the link is even stronger than d1m. Worsening epidemic type 2 dm: aging population - prevalence with age. In canada: now 1. 9 million dm, in 2016 est. 2. 7 million dm (old stats even worse #s now) Major metabolic defects in type 2 diabetes: peripheral insulin resistance in muscle and fat. Counteracting the action of insulin: decreased pancreatic insulin secretion. As the b-islet (insulin-producing) cells atrophy, no longer produce insulin & you have: B/c the liver thinks you"re in the fasting state even though you"re not. Insulin resistance important abnormality: often primary abnormality; major role in development of type 2 dm. 1 present 10-20 years before onset of disease. 2 consistent finding in patients with type 2 dm. 3 best single predictor of whether an individual will later become diabetic (d2m)
