BIOL 4285 Lecture Notes - Lecture 6: Tsc1, Fusion Protein, Xist (Gene)
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Because its an end point has to do with telomerase: mutatio(cid:374) rate: (cid:449)e e(cid:448)ol(cid:448)ed (cid:373)utatio(cid:374)s i(cid:374) order to o(cid:448)er(cid:272)o(cid:373)e age (cid:271)ut it"s a dou(cid:271)le s(cid:449)ord as it can harm you. Slide 3: cancer follows 6 hit model: we need 6 discrete mutation in order to have a tumor. 10^-7 mutation during cell division ge(cid:374)es do(cid:374)"t a(cid:272)(cid:272)u(cid:373)ulate (cid:373)utatio(cid:374) that much. Multiply that by having 10^-42 for 6 cells being mutation. We get a 1 in 10^29 chance. Slide 4: evolution model, successive mutation that gives a rise for a population to grow. As mutation evolves that would leads to mutating all the cells to make them susceptible and they can have futher mutations as said we need 6 mutations. There should be a mutation in the dna repair mechanism higher chance of getting cancer genomic instability (happens early in mutagenisis) Genomic stability: atm: kinase regulates p53 and brca 1 and 2. Mutation in atm hyper sensitive to uv.
