BIOL 4285 Lecture Notes - Lecture 3: Genetic Screen, Logarithm, Sv40
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Huntington: cag encoding for glutamine q, polyq found in the n terminus of the huntington the expansion of the cag is in the coding region. Acts as a dominant negative that inhibits the endogenous. You only need to inherit one copy that has the repeat which would increase the possibility of having the disease: slide 3: The higher the number of repeats the earlier the onset of the disease in individuals. Direct proportionality circles at 50 years old means the person has the trinucleotide repeats but does(cid:374)"t sho(cid:449) the sy(cid:373)pto(cid:373)s. Plus means that the individual is normal. Majority of people have 20-28 repeats long: slide 4: The q"s fou(cid:374)d its (cid:449)ay i(cid:374)to the hu(cid:374)ti(cid:374)gto(cid:374) disease. Once you have a certain number of repeats it can undergo anticipation and then leads to the mutation and thus the disease. Take the genes that has the nucleotides and do pcr and analyse the length.
